What is JASS: A python package to perform Multi-trait GWAS

JASS is a Python package that handles the computation of joint statistics over sets of selected GWAS results through a command-line tool.

More precisely, users can perform multi-trait GWAS and display static plots of the results on their own data through the command-line interface. The functionality of this package can be explored on a web server, https://jass.pasteur.fr/, which allows users to perform multi-trait GWAS on a database of 184 summary statistics.

In this documentation, we cover the steps required for installing the software and illustrate its usage through examples.

We also briefly describe in the next section the pre-processing of raw GWAS data, which can be performed through a companion Nextflow pipeline provided alongside the JASS package.

For method details and applications, check out our publications related to JASS or its accompanying packages (RAISS).

JASS application paper [JLM+21]

Study on the statistical power of JASS [SMenagerB+24]

JASS computational architecture [JLG+20]

RAISS [JSPA19]